Which of the following statements regarding HSCs is/are TRUE?
I.HSCs are not self-renewing.
II.HSCs can make copies of themselves.
III.HSCs give rise to one cell lineage.
IV.HSCs are multipotent.
V.HSCs express both RAG1 and RAG2 surface markers.

Question

Quizplus · Accepted Answer

Hematopoietic stem cells (HSCs) are indeed self-renewing, which contradicts statement I, and they are multipotent, meaning they can give rise to multiple cell lineages, not just one as stated in III. This makes statements II and IV correct. HSCs expressing RAG1 and RAG2 surface markers is not accurate for identifying HSCs, as these genes are involved in recombination activities specific to lymphocyte development.

Which of the Following Statements Regarding HSCs Is/are TRUE