In people infected with human cytomegalovirus, class I MHC and ? ₂-microglobulin are produced, but very little mature class I MHC is found at the cell surface.Inhibition of which of the following molecules by human cytomegalovirus may account for this phenomenon?

Question

Quizplus · Accepted Answer

Human cytomegalovirus inhibits the transporter associated with antigen processing (TAP), which is essential for the transport of peptides into the endoplasmic reticulum for loading onto MHC class I molecules. This inhibition leads to reduced presentation of viral antigens on the cell surface, helping the virus evade the immune system.

In People Infected with Human Cytomegalovirus, Class I MHC and