This antimalarial agent is a prodrug that is metabolized to cycloguanil, a dihydrofolate reductase inhibitor, which results in blocking deoxythymidine synthesis and stops DNA synthesis?

Question

Quizplus · Accepted Answer

Proguanil is metabolized in the body to cycloguanil, which is a dihydrofolate reductase inhibitor. This action blocks the synthesis of deoxythymidine, an essential component of DNA, thereby inhibiting DNA synthesis and stopping the growth of the malaria parasite.

This Antimalarial Agent Is a Prodrug That Is Metabolized to Cycloguanil