Examples of Enzymatic Modification of an Antimicrobial Agent's Structure or an Antimicrobial

Examples of enzymatic modification of an antimicrobial agent's structure or an antimicrobial agent's target include ________. (Select all that apply)

A) methylization of the 38S rRNA that prevents antimicrobial agents from binding to inhibitory site on the bacterial ribosome
B) expression of PBP2A that prevents beta-lactam antibiotics from binding to the penicillin binding protein and shutting down enzymatic production of peptidoglycan
C) production of beta-lactamase that degrades the beta-lactam ring and prevents the antibacterial agent from binding to the penicillin binding protein
D) production of chloramphenicol acetyl transferase, an enzyme that chemically modifies and inactivates chloramphenicol