The compound MOST responsible for global climate change is:

Name: The compound MOST responsible for global climate change is:
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Carbon dioxide (CO2) is the primary greenhouse gas emitted through human activities, especially the burning of fossil fuels, deforestation, and various industrial processes. It is the most significant contributor to global warming and climate change, trapping heat in the Earth's atmosphere and leading to a rise in global temperatures.

The Compound MOST Responsible for Global Climate Change Is