Which of the following statements is true regarding the therapeutic index (TI)of a drug?

Question

Quizplus · Accepted Answer

The therapeutic index (TI) is defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50) of a drug. Therefore, option D is the correct statement. Option A is incorrect, as a drug with a larger TI is considered safer since the dose required to produce toxic effects is much higher than the effective dose. Option B is incorrect since the formula for TI is LD50/ED50, not ED50/LD50. Option C is also incorrect since the effective clinical dose is the dose that produces the desired therapeutic effect in 50% of the population, not 50% of the effective dose.

Which of the Following Statements Is True Regarding the Therapeutic