Enterohepatic circulation of a drug involves the secretion of a metabolized drug into the intestine.If enterohepatic circulation is blocked,the level of the drug in the serum will fall.

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Quizplus · Accepted Answer

Both statements are true.Enterohepatic circulation involves the secretion of a metabolite,such as a conjugated drug,via the bile into the intestine.While in the intestine,the metabolite is broken down (deconjugated),and the active drug can be reabsorbed into the circulation.If this process is blocked,then the reactivated drug cannot reenter the circulation,and the serum level will fall accordingly.Both of the statements are true as written.The circular pattern continues with some drug escaping with each passing.This process prolongs the effect of a drug.

Enterohepatic Circulation of a Drug Involves the Secretion of a Metabolized