In an assessment of drug action for a certain therapeutic agent,results indicate that the ED₅₀ is 3 mg/kg,and the LD₅₀ is 300 mg/kg.What is the therapeutic index for this agent?

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If the value of the TI is small,then toxicity is more likely.If the TI is large,then the drug will be safer.A drug with a wide TI will have a large LD₅₀ and a small ED₅₀ (the distance between these curves is large).A TI of greater than 10 is usually needed to produce a therapeutically useful drug.One must divide the LD₅₀ value by the ED₅₀ value.The LD₅₀ value (300)divided by the ED₅₀ value (3)equals 100.

In an Assessment of Drug Action for a Certain Therapeutic