Which of the following describes ketoconazole? (Select all that apply. )

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An acidic environment is required for the adequate systemic absorption of ketoconazole.Medications that interfere with the normal production of stomach acid,such as histamine-2 (H₂)-blockers or H₂-receptor antagonists and proton pump inhibitors,could theoretically reduce the absorption of ketoconazole.Ketoconazole and other imidazoles interact with warfarin.This may increase warfarin blood levels and increase the risk for bleeding.Incorrect choices: The imidazoles inhibit the C-14 demethylation of lanosterol,an ergosterol precursor.By interfering with the synthesis of ergosterol membrane permeability is altered and purine transport inhibited.Ketoconazole is not the drug of choice for the treatment of tinea unless traditional agents have failed.

Which of the Following Describes Ketoconazole? (Select All That Apply