Several cases of methemoglobinemia have been reported after the use of

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Although the toxicity of prilocaine is 60% of that occurring with lidocaine,several cases of methemoglobinemia have been reported after its use.Prilocaine is metabolized to orthotoluidine and,in large doses,can induce some methemoglobinemia.Although the small doses required in dental practice are not likely to present a problem in healthy,nonpregnant adults,prilocaine should not be administered to patients with any condition in which problems of oxygenation may be especially critical.Methemoglobinemia is a rare hereditary condition in which there is an inability of the blood to bind to oxygen.It is not associated with the remaining choices of dental local anesthetic.

Several Cases of Methemoglobinemia Have Been Reported After the Use