Which Two Agents Are Known to Cause Clinically Significant Drug

Which two agents are known to cause clinically significant drug interactions when combined with epinephrine?

A) Selective serotonin reuptake inhibitors and b-adrenergic antagonists
B) β-Adrenergic antagonists and phenothiazines
C) Tricyclic antidepressants and monoamine oxidase inhibitors
D) b-Adrenergic antagonists and tricyclic antidepressants
E) Benzodiazepines and monoamine oxidase inhibitors