The use of barbiturates is absolutely contraindicated in patients with a positive family history of

Question

The use of barbiturates is absolutely contraindicated in patients with a positive family history of

Quizplus · Accepted Answer

The use of barbiturates is absolutely contraindicated in patients with intermittent porphyria or a positive family history of porphyria because barbiturates can stimulate and increase the synthesis of porphyrins,which are already at an excessive level in this metabolic disease.In fact,the barbiturates have been reported to precipitate an acute attack of porphyria.The remaining choices are not absolute contraindications to the use of barbiturates.

The Use of Barbiturates Is Absolutely Contraindicated in Patients with a Positive