Phenothiazines cause orthostatic hypotension by blocking which receptor?

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Phenothiazines,first-generation antipsychotics,cause orthostatic hypotension by blocking a-adrenergic receptors.These agents depress the central sympathetic outflow and block the peripheral adrenergic receptors;they can produce orthostatic hypotension that is additive with other CNS depressants.When a patient rises rapidly from the supine position,a compensatory tachycardia can accompany the orthostatic hypotension.

Phenothiazines Cause Orthostatic Hypotension by Blocking Which Receptor