Which of the following statements is the mechanism of action of nonsulfonylurea secretagogues such as repaglinide (Prandin) and nateglinide (Starlix) ?
A) They are competitive, reversible inhibitors of GI tract enzymes: intestinal α-glucosidase and pancreatic α-amylase.
B) They increase the insulin sensitivity of adipose tissue, skeletal muscle, and the liver.
C) They increase hepatic and peripheral insulin sensitivity, resulting in decreased hepatic glucose production.
D) They bind to adenosine triphosphate (ATP) sensitive potassium channels on beta cells and increase insulin resistance.
Correct Answer:
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