The U.S.Food and Drug Administration (FDA)recommends checking serum alanine aminotransferase (ALT)levels before starting therapy with _____ and periodically thereafter.

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Hepatotoxicity has rarely been reported with rosiglitazone and pioglitazone.These drugs should not be used in patients with underlying liver disease or with ALT levels greater than 2.5 times the upper limit of normal.The FDA recommends checking serum ALT levels before starting therapy with thiazolidinediones and periodically thereafter.

The USFood and Drug Administration (FDA)recommends Checking Serum Alanine Aminotransferase (ALT)levels