The Swiss physician Paracelsus' argument that illness was caused by external agents was a radical challenge to the prevailing medical theory of humours.

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Paracelsus' theory was indeed radical for its time as it challenged the prevailing humoral theory, which was based on the balance of four bodily fluids. He proposed that disease was the result of external agents, such as chemicals, rather than imbalances within the body, marking a significant shift in medical thought.

The Swiss Physician Paracelsus' Argument That Illness Was Caused by External