How Do Adrenergic Receptors in Prefrontal Cortex Neurons Respond to Norepinephrine

How do adrenergic receptors in prefrontal cortex neurons respond to norepinephrine?

A) they are excited by α-1 receptor activation and inhibited by α-2 activation
B) they are excited by α-2 receptor activation and inhibited by α-1 activation
C) they only express α-1 receptors that are inhibited by norephinephrine
D) they are inhibited at low levels of norepinephrine and excited as more norepinephrine is released.
E) all of the above