The rhythmic depolarization and hyperpolarization of a lamprey's spinal column persists even in the presence of TTX. How does this support the central pattern generator hypothesis?

Question

Quizplus · Accepted Answer

The presence of TTX (tetrodotoxin) blocks sodium channels, preventing action potentials from occurring between neurons. The fact that rhythmic depolarization and hyperpolarization continue despite this blockade supports the central pattern generator hypothesis, which posits that networks of neurons can generate rhythmic patterns of output without requiring sensory feedback or input from higher brain regions. This indicates that the pattern generation is intrinsic to the spinal cord's neural circuits themselves.

The Rhythmic Depolarization and Hyperpolarization of a Lamprey's Spinal Column