Given your knowledge of the mechanism of action of sildenafil citrate (Viagra), what would be the most important factor to consider before in assessing if a patient has the adequate medical profile for this drug?

Question

Quizplus · Accepted Answer

Sildenafil citrate works by inhibiting phosphodiesterase type 5 (PDE5), which leads to an increase in cyclic guanosine monophosphate (cGMP) levels, causing smooth muscle relaxation and vasodilation in the corpus cavernosum, thereby facilitating erection. However, it can also cause systemic vasodilation, which can be dangerous in patients with chronic hypertension, especially those on nitrates, as it can lead to severe hypotension. The other options (A, C, D) are not directly related to the mechanism of action of sildenafil or its potential contraindications.

Given Your Knowledge of the Mechanism of Action of Sildenafil