Which analysis of maternal serum may predict chromosomal abnormalities in the fetus?

Question

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Maternal serum can be analyzed for abnormal levels of alpha-fetoprotein,human chorionic gonadotropin,and estriol.The multiple-marker screening may predict chromosomal defects in the fetus.The L/S ratio is used to determine fetal lung maturity.A BPP is used for evaluating fetal status during the antepartum period.Five variables are used,but none is concerned with chromosomal problems.The blood type and crossmatch would not predict chromosomal defects in the fetus.

Which Analysis of Maternal Serum May Predict Chromosomal Abnormalities in the Fetus