These antidepressants inhibit the brain's reuptake of several neurotransmitters, primarily norepinephrine and serotonin, thus prolonging activity of these chemicals at synapses.

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Tricyclic antidepressants work by inhibiting the reuptake of norepinephrine and serotonin, thus increasing their levels and activity in the brain. This contrasts with selective serotonin reuptake inhibitors (SSRIs) that specifically target serotonin, MAO inhibitors that prevent the breakdown of neurotransmitters, and barbiturates, which are not antidepressants but sedatives affecting the central nervous system.

These Antidepressants Inhibit the Brain's Reuptake of Several Neurotransmitters, Primarily