The primary care NP is preparing to prescribe isosorbide dinitrate sustained release (Dilatrate SR)for a patient who has chronic,stable angina.The NP should recommend initial dosing of:

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Long-acting nitrates should be considered to treat chronic,stable angina.The main limitation is tolerance,which can be limited by providing a nitrate-free period of 6 to 10 hours each day.The medication should be taken on an empty stomach,30 to 60 minutes before a meal.An appropriate initial dose of isosorbide dinitrate is 40 mg every 12 hours.This dose can be increased as needed.Isosorbide mononitrate is given on awakening and again 7 hours later.The medication is not given four times daily.Dosing may be increased to 80 mg tid,and the dosing schedule of 8:00 AM,1:00 PM,and 6:00 PM.would be appropriate at that point.

The Primary Care NP Is Preparing to Prescribe Isosorbide Dinitrate