The extended consumption of heroin, morphine, or methadone leads to cessation of production of enkephalin, which is a natural painkiller. This is an example of:

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Dependence occurs when the body adjusts to the presence of a drug, such as heroin, morphine, or methadone, leading to the cessation of natural painkiller (enkephalin) production. This adjustment means the body relies on the drug to function normally.

The Extended Consumption of Heroin, Morphine, or Methadone Leads to Cessation