Down Syndrome Has a Frequency in the Canadian Population of ~4/10,000

Down syndrome has a frequency in the Canadian population of ~4/10,000 live births.In which of the following groups would you expect this frequency to be significantly higher?

A) people in Latin or South America
B) the Inuit and other peoples in very cold habitats
C) people living in equatorial areas of the world
D) very small population groups
E) No groups have such higher frequency.