The First Class of Drugs Developed to Treat AIDS,such as AZT,were

The first class of drugs developed to treat AIDS,such as AZT,were known as reverse transcriptase inhibitors.Why did they work?

A) AZT targets and destroys the viral genome before it can be reverse transcribed into DNA.
B) AZT interacts with the dsDNA genome of the virus in such a way that replication cannot occur.
C) AZT interacts with viral reverse transcriptase enzyme, thus preventing the virus from making a DNA copy of its RNA genome.
D) AZT prevents host cells from producing the enzymes used by the virus to replicate its genome.
E) AZT inhibits the virus from binding to host cells.