Which of the Following Is the Best Definition of Autoimmune

Which of the following is the best definition of autoimmune disease?

A) a condition in which B cells and T cells respond independently to antigens and do not interact correctly
B) a condition in which the adaptive immune system fails to recognize the second infection by the same antigen
C) a condition in which self molecules are treated as non-self
D) a condition in which the immune system creates random antibodies without being triggered by an antigen
E) a condition where the individual produces too much IgE and the result is excessive histamine release when encountering environmental antigens