Tetrodotoxin blocks voltage-gated sodium channels and ouabain blocks sodium-potassium pumps.If you added both tetrodotoxin and ouabain to a solution containing neural tissue,what responses would you expect?

Question

Quizplus · Accepted Answer

Tetrodotoxin blocks voltage-gated sodium channels, which are responsible for generating action potentials, so adding it to a neural tissue solution would result in an immediate loss of action potential. Ouabain, on the other hand, blocks sodium-potassium pumps, which help to maintain the resting potential, so over time the resting potential would gradually be lost. Combining both substances would result in an immediate loss of action potential and a gradual loss of resting potential.

Tetrodotoxin Blocks Voltage-Gated Sodium Channels and Ouabain Blocks Sodium-Potassium Pumps