In theory,a COX-2 selective drug such as celecoxib will be less likely to cause gastric irritation because

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COX-2 selective drugs do not inhibit the production of beneficial prostaglandins in the stomach, which means they are less likely to cause gastric irritation. Traditional NSAIDs inhibit COX-1, which produces prostaglandins that protect the stomach lining. By inhibiting COX-1, traditional NSAIDs can lead to gastric irritation and ulcers. Therefore, COX-2 selective drugs, such as celecoxib, are less likely to cause these adverse effects because they do not affect the production of protective prostaglandins in the stomach.

In Theory,a COX-2 Selective Drug Such as Celecoxib Will Be