Certain beta-blockers such as pindolol and acebutolol are valuable because they block the effects of excessive endogenous catecholamines while still producing a normal background level of sympathetic stimulation to the heart.These beta blockers are said to have

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These beta-blockers have intrinsic sympathomimetic activity (ISA), meaning they can partially activate beta-adrenergic receptors while blocking the effects of more potent endogenous catecholamines. This allows for a baseline level of sympathetic activity to be maintained, which can be beneficial in certain clinical scenarios.

Certain Beta-Blockers Such as Pindolol and Acebutolol Are Valuable Because