Overuse of Beta Agonists Should Be Avoided in People with Bronchospastic

Overuse of beta agonists should be avoided in people with bronchospastic disease because

A) excessive use of these drugs may cause tolerance
B) excessive use may stimulate the cardiovascular and central nervous systems
C) excessive use of these drugs may promote airway irritation, thus increasing the incidence and severity of bronchospastic attacks
D) all the above are true
E) none of the above are true