Historians and demographers have studied multicides (events and periods and regimes during which killed huge numbers of humans have been killed) and genocides (in which certain specific ethnic, national, and racial categories have been deliberately exterminated). The worst multicide in human history was:

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World War II is widely considered to be the worst multicide in human history, with an estimated death toll of around 70 million people. This includes both civilians and military personnel, as well as victims of genocide, such as the Holocaust. The other options listed, while significant and devastating events in their own right, did not result in as high a death toll.

Historians and Demographers Have Studied Multicides (Events and Periods and Regimes