Most Anticancer Drugs Exert Severe and Potentially Toxic Side Effects

Most anticancer drugs exert severe and potentially toxic side effects because

A) these drugs have a high therapeutic index (TI)
B) most of these drugs are not approved by the FDA
C) most of these drugs do not discriminate between healthy tissues and cancerous cells
D) these drugs all have extremely long half-lives, and tend to accumulate in the body for an extended period of time
E) the threshold dose of these drugs is typically much higher than other drugs