Fat necrosis typically found in and around the pancreas in acute pancreatitis is caused by a release of:

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Fat necrosis in acute pancreatitis is caused by the release of lipase, which breaks down triglycerides into free fatty acids and glycerol. The free fatty acids then combine with calcium ions to form insoluble calcium soaps, which can accumulate in the pancreas and surrounding tissue, leading to necrosis. Amylase, peptidase, pepsin, and cholecystokinin are not directly involved in fat necrosis in pancreatitis.

Fat Necrosis Typically Found in and Around the Pancreas in Acute