Over the course of American history, social issues such as religious toleration, slavery, and, most recently, the decision by some states to permit marijuana use, have strained reciprocity and cooperation between the states.

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Throughout American history, social issues have often caused tension and division between states, affecting reciprocity and cooperation. Examples include the debates over religious toleration in the early colonies, the conflict over slavery leading up to the Civil War, and the current disagreement over the legalization of marijuana in some states.

Over the Course of American History, Social Issues Such as Religious