Giving depressed patients a placebo rather than an actual drug:

Question

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Research has shown that giving depressed patients a placebo can alleviate depressive symptoms in roughly one-third of patients, although the exact mechanism of this effect is not fully understood. It is important to note, however, that some patients may report feeling better simply because they believe they are receiving a treatment, even if the placebo has no actual effect on their condition.

Giving Depressed Patients a Placebo Rather Than an Actual Drug