Which of the Following Most Likely Explains the Physiological Response

Which of the following most likely explains the physiological response to noxious-level stimulation (hyperstimulation) that results in analgesia?

A) Release of endogenous opioids in the central nervous system
B) Closing the "gate" to nociception in the spinal cord
C) Blocking of nociceptive receptors in the skin
D) Release of histamine and prostaglandins into the circulatory system