The allele for sickle-cell anemia is found primarily in areas where there are large populations of mosquitoes bearing:

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The allele for sickle-cell anemia is actually a genetic adaptation to falciparum malaria. Having one copy of the gene provides some resistance to malaria, but having two copies results in the severe condition of sickle-cell anemia. The prevalence of this allele is highest in areas where falciparum malaria is endemic, such as sub-Saharan Africa, parts of India and the Middle East, and some parts of South America. Mosquitoes are the primary vector for transmitting malaria, but the other diseases listed (parasitic dysentery, smallpox, yellow fever) do not have a direct correlation to sickle-cell anemia.

The Allele for Sickle-Cell Anemia Is Found Primarily in Areas