Which of the Following Statements About Nutritional Energetics Is FALSE

Which of the following statements about nutritional energetics is FALSE?

A) The dynamic relationship between energy intake and expenditure has important consequences for human health, reproduction and survival.
B) Physical activity increases energy expenditure and can help regulate eating behaviour.
C) Adenosine monophosphate (AMP) -activated protein kinase (AMPK) is a crucial cellular energy sensor that maintains energy homeostasis, and its impaired activation can cause the so-called metabolic syndrome.
D) Restricting food intake without accompanying increased physical activity can cause a loss of fat tissue and has no effect on muscle mass.
E) Being physically active can weaken the obesity-increasing effect of certain variants of the fat mass and obesity-associated (FTO) gene.