Clearance of an acidic drug by the kidneys may be increased by:

Question

Quizplus · Accepted Answer

Alkalising the urine increases the ionization of acidic drugs, promoting their elimination through renal excretion. This can be achieved by administering substances that increase the pH of the urine, such as sodium bicarbonate or citrate, which bind to hydrogen ions and reduce their concentration in the urine. Administering amphetamines or ascorbic acid is unlikely to increase renal clearance of an acidic drug.

Clearance of an Acidic Drug by the Kidneys May Be