Glyceryl trinitrate is almost 96 per cent destroyed by the liver on its first journey through. It is therefore referred to having a:

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Glyceryl trinitrate is almost 96% destroyed by the liver on its first journey through, which indicates a high hepatic first-pass effect. This means that a significant portion of the drug is metabolized by the liver before it even enters the systemic circulation, reducing its bioavailability.

Glyceryl Trinitrate Is Almost 96 Per Cent Destroyed by the Liver