In terms of the proposed sites of action of antidepressant drugs, which of the following would be expected to produce a therapeutic benefit?

Question

Quizplus · Accepted Answer

Antidepressant drugs are expected to increase the synaptic levels of neurotransmitters serotonin and/or noradrenaline, as low levels of these neurotransmitters are associated with depression. Monoamine oxidase inhibitors (MAOIs) would result in an increase in neurotransmitter levels, but this is not the primary mechanism of action, and the induction of MAO activity would actually decrease neurotransmitter levels. A centrally acting β agonist is not typically used as an antidepressant. Depletion of amine transmitter levels in the presynaptic nerve terminal would exacerbate depression symptoms.

In Terms of the Proposed Sites of Action of Antidepressant