The actions of streptomycin and amikacin:

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Both streptomycin and amikacin belong to the class of antibiotics known as aminoglycosides, which exert their bactericidal action by irreversibly binding to the 30S subunit of bacterial ribosomes, thereby interfering with protein synthesis. This disruption of protein synthesis results in the inability of bacteria to form functional cell walls, ultimately leading to bacterial cell death. However, these antibiotics are not currently considered first-line for tuberculosis therapy due to concerns about resistance and toxicity. Additionally, aminoglycosides are primarily administered parenterally, as they are not well absorbed orally.

The Actions of Streptomycin and Amikacin