What was the most deadly of the epidemics in the Americas?

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Smallpox was responsible for the deaths of millions of indigenous people in the Americas, particularly after the arrival of European colonizers who brought the disease with them. It decimated entire communities and significantly impacted the social and cultural fabric of the region. While other diseases also had devastating effects, such as syphilis and measles, smallpox was particularly lethal and had a profound and lasting impact on the Americas.

What Was the Most Deadly of the Epidemics in the Americas