A significant weakness of the Ottoman Empire against the Portuguese was that, originally, the Ottomans did not have:

Name: A significant weakness of the Ottoman Empire against the Portuguese was that, originally, the Ottomans did not have:
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The Ottoman Empire initially lacked a strong navy capable of challenging the Portuguese and other Christian naval forces, which was a significant weakness in their efforts to control trade routes and expand their influence in the Indian Ocean.

A Significant Weakness of the Ottoman Empire Against the Portuguese