From their cross-cultural study of small, homogeneous societies, MacAndrew and Edgerton conclude that behavior under the influence of alcohol is primarily a function of:

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MacAndrew and Edgerton conclude that behavior under the influence of alcohol is primarily a function of social expectations concerning drunken behavior rather than other factors such as toxicity, amount consumed, or genetic disposition. They found that different cultures have different expectations of how people should behave when drinking, and individuals tend to conform to these expectations.

From Their Cross-Cultural Study of Small, Homogeneous Societies, MacAndrew and Edgerton