What international document was developed in 1949 to direct investigators in conducting ethical research?

Question

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The development of the Nuremberg Code in 1949 addressed the mistreatment of human subjects.
The Declaration of Helsinki was adopted in 1964.
The Department of Health, Education, and Welfare regulations were published in 1973 providing for the protection of human research subjects.
The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research was formed in 1978. It was established by the National Research Act, which passed in 1974.

What International Document Was Developed in 1949 to Direct Investigators