Methotrexate interferes with the metabolism of _____.

Question

Methotrexate interferes with the metabolism of _____.​

Quizplus · Accepted Answer

Methotrexate is an anti-metabolite drug that interferes with the metabolism of folate, a B-vitamin that is essential for the synthesis of DNA, RNA, and proteins. By inhibiting the enzyme dihydrofolate reductase, which converts folic acid into its active form, methotrexate reduces the availability of folate and impairs cell proliferation and division. This makes it effective in treating cancer, autoimmune diseases, and ectopic pregnancy, but it can also cause side effects such as anemia, neutropenia, and mucositis. Patients taking methotrexate are often prescribed folic acid supplements to mitigate these effects.

Methotrexate Interferes with the Metabolism of _____.​

Methotrexate Interferes with the Metabolism of _____.