Which compound(s) formed in the body during an episode of hyperglycemia can alter protein structures and stimulate damaging metabolic pathways?

Question

Which compound(s) formed in the body during an episode of hyperglycemia can alter protein structures and stimulate damaging metabolic pathways?​

Quizplus · Accepted Answer

Advanced glycation end products (AGEs) are formed when glucose reacts with proteins through a non-enzymatic process called glycation. During hyperglycemia, there is an increase in glucose concentration in the blood which leads to an increase in glycation reactions and ultimately the formation of AGEs. These compounds can alter protein structures and stimulate damaging metabolic pathways, leading to tissue damage and complications of diabetes. Sorbitol (A) and fructosamine (E) are also formed during hyperglycemia but do not have as significant an impact on protein structure and metabolic pathways as AGEs do. Glycophosphate (B) is not a compound formed during hyperglycemia, whereas low-density lipoproteins (D) are involved in lipid metabolism and not related to the formation of AGEs during hyperglycemia.

Which Compound(s) Formed in the Body During an Episode of Hyperglycemia