The uptake of neutral amino acids such as leucine, histidine, and valine is inhibited in brain cells of PKU individuals.

Question

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PKU individuals have a deficiency in phenylalanine hydroxylase, leading to high levels of phenylalanine in the blood. This excess phenylalanine can compete with neutral amino acids for transport across the blood-brain barrier and into brain cells, leading to an inhibition in their uptake. This can affect brain development and function in PKU individuals.

The Uptake of Neutral Amino Acids Such as Leucine, Histidine