In positional cloning, the inheritance of a disease in a pedigree was linked to the inheritance of
A) other diseases or conditions.
B) a specific blood type.
C) other genes whose loci were known.
D) marker sequences produced by restriction enzymes.
E) all of these.

Question

Quizplus · Accepted Answer

Positional cloning involves identifying the location of a disease-causing gene on a chromosome. This is done by looking for genetic markers, such as those produced by restriction enzymes, that are closely linked to the disease gene. Therefore, the inheritance of a disease in a pedigree would be linked to the inheritance of these marker sequences. The other choices are not necessarily linked to the disease-causing gene and do not play a direct role in the process of positional cloning.

In Positional Cloning, the Inheritance of a Disease in a Pedigree